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[22] reviewed the characteristics of the nasal delivery devices in general and the aerosol generation to achieve the clinical target of nasal drug delivery to the nose cavity, whether the substance in question has local action, is intended for systemic absorption, N-to-B transport, or a combination [22]

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However, we should consider stress lesions[85] as cytoprotection before Robert’s cytoprotection[14-16], and thereby, Selye’s “stress view”[85]