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Most importantly, this protective phenotype appears to involve the following beneficial cellular adaptions: (i) enhanced metabolism of ethanol and acetaldehyde, (ii) suppression of lipogenic genes and induction of genes involved in fatty acid oxidation, and (iii) induction of the NRF2 antioxidant response and the AMPK metabolic signaling pathway

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While the studies summarized above demonstrate that GPx3 can influence intracellular redox signaling, it still remains largely unclear if enhanced or reduced oxidant scavenging by GPx3 has consequences on the extracellular tumor environment and tumor associated cells