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The copper is not an additive bolted on afterwards: the histidine imidazole, the free amino terminus and a backbone nitrogen form a high-affinity chelation site, which is why the literature treats GHK as a copper-transport peptide rather than a peptide that happens to have a metal nearby

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Between now and those two dates, expect the agency to continue updating the 503A bulks reference document as nominations come in, get withdrawn, get clarified, and shift between categories