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By inhibiting NNMT, 5-Amino-1MQ reduces 1-MNA formation and alleviates the methyl โsink,โ increasing SAM availability for other methylation reactions, while freeing nicotinamide for recycling through NAMPT toward NADโบ
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Funding: This work was supported by the Canadian Institutes of Health Research Grant FDN154299 (to M.I.C.)