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Of note, the analysis by western blot revealed that the levels of enzymes involved in dTTP biosynthesis, like R1 and R2 subunits of ribonucleotide reductase (RNR), thymidylate synthase (TS), thymidylate kinase (TMPK), and thymidine kinase 1 (TK1), were similar in WT and T315I-Bcr-Abl cells (Supplementary Fig