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Dihexa: Powerful Peptide for Brain Health and Regeneration | Joy Kong, MD posted on the topic | LinkedIn

At the same time, pyruvate accumulation stabilizes and activates hypoxia-induced factor-1α (HIF-1α) (even in the body’s physiological oxygenated state) which increases oxidative stress and induces an inflammatory response in the form of, for example, activation of nuclear factor kappa-B (NF-κB) and increased expression of tumor necrosis factor-α (TNF-α) [60,61] (Figure 3)

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It can be especially appealing if you feel depleted, have a demanding schedule, travel often, or want to be more proactive about how you feel week to week