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Interventions that reduce the severity of anaemia from severe to moderate, or from moderate to mild, will deliver large improvements in well-being, but are not recognised as a reduction by the metric of overall prevalence
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Notably, TPP⁺ conjugates such as 3-carboxy-proxyl nitroxide (Mito-CP) and Metformin (Mito-Met10) have been shown to directly activate ULK1 [501], a key initiator of mitophagy, thereby promoting an anti-tumor mitophagy response
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