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Future studies will investigate if there are significant, positive effects on MACE: SURPASS CVOT (cardiovascular risk assessment, NCT04255433) will finalize in 2024 and SURMOUNT-MMO (reduction in morbidity and mortality in adults with obesity, NCT05556512) will finalize in 2027
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In the Tbx1 +/− brain, in addition to increased MMA, we found several metabolites related to the glutamate pathway and to mitochondrial activity to be dysregulated
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