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GSTs play a cytoprotective role primarily by catalyzing the conjugation of reactive electrophiles generated by cytochrome P450 metabolism, using GSH as a cosubstrate, as well as the reduction of hydroperoxides to eliminate toxic products of xenobiotic biotransformation and oxidative stress [20]

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Peroxiredoxin 3 (Prx3) is especially located in the mitochondria and has direct peroxidase and signaling activities