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demonstrated that lidocaine protects isolated rat hearts from changes caused by peroxyl radicals at concentrations of 50 or 200 µM ( in vitro , with lidocaine being the most effective at the lowest concentration of 50 μg/mL ( Accordingly, this study aimed to investigate whether three local anesthetics - lidocaine, bupivacaine, and ropivacaine - can act as free radical scavengers both in aqueous and lipophilic environments, simulating extracellular fluid or cytosol and cellular membranes, respectively
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