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More sophisticated regimens seek dosing not greater than 6 mg/kg/day based on actual body weight (ABW) [97] or 6.0–6.5 mg/kg/day based on IBW for hydroxychloroquine [78, 133]

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To this end, future research should prioritize a deeper understanding of the regulatory mechanisms governing LAT1 expression, which could inform the development of combination therapies tailored to individual patient profiles