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Adamax (Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ala-Gly-NH2) is a synthetic nine-amino-acid peptide and structural analog of Semax, which is itself derived from the ACTH(4-10) fragment
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As a crucial signaling molecule, RA exerts its biological effects by binding to the nuclear receptors RAR/RXR, thereby regulating downstream gene expression networks that govern critical cellular processes, including differentiation, proliferation, and fate determination (Figure 1, studies have revealed distinct expression patterns of ALDH1A1 and ALDH1A3 in prostate cancer tissues that correlate with clinical outcomes
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